L4376
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L4376
Sigma
α-Lobeline hydrochloride
~95% (HPLC), powder
| Synonym: | |
| CAS Number: | 134-63-4 |
| Linear Formula: | C22H27NO2 · HCl |
| Molecular Weight: | 373.92 |
| Beilstein Registry Number: | 3920196 |
| EC Number: | 205-150-2 |
| MDL number: | MFCD00082455 |
Description
| Biochem/physiol Actions | Agonist at high-affinity neuronal nicotinic acetylcholine receptors; respiratory stimulant. Inhibits synaptosomal accumulation of dopamine by interaction with the tetrabenazine binding site of the vesicular monoamine transporter (VMAT2). Blocks amphetamine-induced dopamine release. |
Properties
| assay | ~95% (HPLC) |
| form | powder |
| color | white to off-white |
| solubility | H2O: 25 mg/mL |
| Gene Information | human ... SLC18A2(6571) |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 23/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 1544 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | OJ8490100 |
References
| reference | Toth, P.T. and Vizi, E.S., Lobeline inhibits Ca2+ current in cultured neurones from rat sympathetic ganglia. Eur. J. Pharmacol. 363, 75-80, (1998) |
| Damaj, M.I., et al., Pharmacology of lobeline, a nicotinic receptor ligand. J. Pharmacol. Exp. Ther. 282, 410-419, (1997) | |
| Vizi, E.S., and Lendvai, B., Modulatory role of presynaptic nicotinic receptors in synaptic and non-synaptic chemical communication in the central nervous system. Brain Res. Brain Res. Rev. 30, 219-235, (1999) | |
| Flammia, D., et al., Lobeline: structure-affinity investigation of nicotinic acetylcholinergic receptor binding. J. Med. Chem. 42, 3726-3731, (1999) | |
| Merck | Merck 13,5572 |
| Beilstein | Beil. 21,V,12,627 |
